Noni Madueke starts for Chelsea, as he has been rewarded for his brilliant performance against Crystal Palace.
Chelsea also welcome back Cole Palmer and Raheem Sterling from suspension, but Sterling is only named on the bench.
See the teams below
Luton starting XI: Kaminski (GK), Mengi, Osho, Kaboré, Barkley, Sambi Lokonga, Brown, Bell, Townsend Sr, Doughty, Adebayo,
Subs: Krul (GK), Andersen, Ogbene, Morris, Woodrow, Chong, Ruddock Mpanzu, Clark, Giles
Chelsea starting XI: Petrovic GK, Gusto, Disasi, Thiago Silva, Colwill, Gallagher, Caicedo, Cole Palmer, Madueke, Jackson, Broja.
Subs: Bettinelli (GK), Bergström (GK), Sterling, Fernández, Mudryk, Nkunku, Maatsen, Gilchrist, Matos