Everton boss Sean Dyche has made just one change to the side that beat Newcastle on Thursday with James Garner coming in for Seamus Coleman.
For Chelsea, Mauricio Pochettino has come up with some surprising changes, following the defeat to Manchester United.
Raheem Sterling, Levi Colwill, Thiago Silva and Nicolas Jackson all drop to the bench as captain Reece James, Conor Gallagher, Benoit Badiashile and Armando Broja come in.
Everton starting XI: Pickford, Young, Tarkowski, Branthwaite, Mykolenko, Garner, Doucoure, Gueye, McNeil, Harrison, Calvert-Lewin.
Subs: Virginia, Godfrey, Patterson, Hunt, Onana, Danjuma, Dobbin, Beto, Chermiti
Chelsea starting XI: Sanchez, James, Disasi, Badiashile, Cucurella, Caicedo, Fernandez, Gallagher, Palmer, Mudryk, Broja.
Subs: Petrovic, Colwill, Gilchrist, Thiago Silva, Maatsen, Matos, Castledine, Sterling, Jackson