Mauricio Pochettino has made two changes to the Chelsea team that started the 3-2 win over Brighton on Sunday.
Conor Gallagher is suspended for this game, and Cole Palmer is back in the starting team.
Marc Cucurella also starts, while Reece James who is available again after suspension was given a place on the bench. Badiashile who started the last game is also on the bench.
Manchester United starting XI: Onana, Dalot, Maguire, Lindelof, Shaw, Amrabat, McTominay, Fernandes, Antony, Garnacho, Hojlund.
Subs: Bayindir, Martial, Rashford, Reguilon, Pellistri, Wan-Bissaka, Van de Beek, Evans, Mainoo.
Chelsea starting XI: Sanchez, Disasi, Thiago Silva, Colwill, Cucurella, Caicedo, Fernandez, Sterling, Palmer, Mudryk, Jackson.
Subs: Petrovic, Badiashile, Broja, James, Maatsen, Deivid, Gilchrist, Matos, Castledine.