Chelsea boss Mauricio Pochettino has made two changes to his starting line-up from the 4-1 win at Burnley.
Malo Gusto and Mykhailo Mudryk come in to replace Axel Disasi and Armando Broja, who picked up a knee knock while on international duty with Albania.
Arsenal also make two changes from their 1-0 win over Manchester City. Bukayo Saka and Gabriel Martinelli replace Eddie Nketiah and Leandro Trossard.
Chelsea starting XI: Sanchez, Gusto, Thiago Silva, Colwill, Cucurella, Gallagher, Caicedo, Fernandez, Palmer, Mudryk, Sterling.
Subs: Disasi, Badiashile, Madueke, Jackson, Ugochukwu, James, Petrovic, Maatsen, Deivid Washington.
Arsenal starting XI: Raya, White, Saliba, Gabriel, Zinchenko, Odegaard, Jorginho, Rice, Saka, Gabriel Jesus, Martinelli.
Subs: Partey, Smith Rowe, Nketiah, Kiwior, Tomiyasu, Trossard, Nelson, Havertz, Hein.
Referee: Chris Kavanagh