Chelsea’s £100m winger, Mykhailo Mudryk was dropped to the bench for Ukraine’s game at the Stadio Giuseppe Meazza away to Italy, on Tuesday night.
The player who has failed to impress Chelsea boss Mauricio Pochettino, was brought in at the 58th minute as a replacement for Andriy Yarmolenko.
Ukraine went into the clash at the Stadio Giuseppe Meazza three points ahead of Italy, who have a game in hand, but the defeat has seen them drop to third place.
England sits at the top of Group C with 13 points from five matches, with the Ukrainians second on seven points from four games.
22-year-old Mudryk cost Chelsea an initial £62m back in January.